I received my M.D. from New York University and house staff training at Bellevue Hospital in NY. My post-doctoral training in Biochemistry was at Harvard Medical School, and in Immunology at Brigham and Women’s Hospital. My original background is in the leukotrienes (bioactive lipids derived from arachidonic acid), enzymology, and inflammation. I am currently interested in how cells integrate the constantly changing array of extracellular signals to achieve an appropriate phenotype via the transient assembly of multiprotein complexes; particularly those held together by weak interactions. My overall management philosophy about labs is best expressed by management rule #3 of the late Kelly Johnson, the founding director of the Advanced Development Program at Lockheed, best known as the Skunk Works: “The number of people having any connection with the project must be restricted in an almost vicious manner. Use a small number of good people (10% to 25% compared to the so-called normal systems)”- In practical terms that translates into giving a relatively small group of outstanding investigators (6-8 max) the best possible equipment, facilities, and working environment.
After earning her Ph.D. in Pharmacology from the University of Illinois at Chicago, where she studied calcium signaling and vascular biology, Angie joined the Soberman Laboratory in 2008. She focuses on understanding the assembly and architecture of the leukotriene synthetic complex in myeloid cells by combining advanced imaging and biochemical techniques. She is supported by a K01 grant which was awarded in firstname.lastname@example.org
John graduated with a BS/MS in Pharmaceutical Sciences/Pharmacology from Northeastern University and is pursuing further graduate education at Harvard University. He has been a member of the lab since 2014. He is studying how 5-LO and FLAP organize on the nuclear membrane in response to different cytokines and how members of prostaglandin synthesis are organized in email@example.com
Zoë is a junior at Harvard College and works as a summer student in the lab. She is working on how 5-LO and FLAP assemble on the nuclear membrane in response to different cytokines and how members of prostaglandin synthesis are organized in firstname.lastname@example.org
Carolyn received her B.S. in Biology from Tufts University and has worked in the Soberman lab since graduating in 2014. She studies the role of CD200R1 in neutrophil biology, as well as assisting with various other projects. She plans to pursue a Ph.D. in email@example.com
Matthew graduated from The University of Connecticut with a Bachelors degree in molecular and cellular biology in 2012. He is focused how the leukotriene biosynthetic complex reorganizes on the nuclear membrane in response to extracellular stimuli and on the role of G-protein signaling in ANCA firstname.lastname@example.org
Peter received his Ph.D. from Liverpool University, U.K. He completed his post-doctoral fellowship in the Soberman laboratory and is now R01 funded. His interests are the biology of Cytochrome P450s, in particular CYP4F3, which controls the inactivation of LTB₄ in PMN and macrophages.
Rachel received her BA from Bates College, and has worked in the Soberman group since graduating in 2011. She will be attending nursing school in the fall.
Christine graduated from the University of Massachusetts, Amherst in 2005 with a B.S. in microbiology. She received her Ph.D. in immunology in 2010 from Dr. Robert Finberg’s laboratory at the University of Massachusetts Medical School in Worcester. Her graduate work focused on imaging antibody-mediated endocytosis pathways as well as characterizing particle-induced innate immune responses. She joined Dr. Soberman’s laboratory as a post-doctoral research fellow in 2010 to study the role of CD200R1 in mediating neutrophil biology.
Melissa received her Ph.D. in Chemistry from Vanderbilt University, where she studied structure-function relationships of cyclooxygenase metabolism and inhibition in the laboratory of Larry Marnett. She joined the Soberman laboratory in 2010. She studies how proteins in the leukotriene synthetic complex organize on the nuclear membrane.